RBD in the News
Expanded NAPS Study Launches
The North American Prodromal Synucleinopathy (NAPS) Consortium was established in 2018 to study REM Sleep Behavior Disorder (RBD), a sleep disorder which causes individuals to talk, move (sometimes violently) or engage in other dream-enacting behavior while asleep and may serve as an indicator of future neurodegenerative disorders such as Parkinson’s disease, dementia with Lewy bodies or multiple system atrophy.
The expanded NAPS study, recently funded by the National Institutes of Health, will enable clinical trials aimed at preventing or slowing neurodegenerative diseases. Goals include studying additional individuals with RBD, developing biomarkers for neurodegenerative diseases and identifying potential drug targets.
The study is led by Dr. Yo-El Ju (Washington University in St. Louis), Dr. Bradley Boeve (Mayo Clinic), and Dr. Ronald Postuma (McGill University Health Centre Research Institute).
Additional institutions and investigators enrolling participants include: Emory University (Dr. Daniel Huddleston), Massachusetts General Hospital (Dr. Aleksandar Videnovic), Mayo Clinic (Dr. Erik St. Louis), Stanford University (Dr. Emmanuel During), University of California Los Angeles (Dr. Alon Avidan), University of Minnesota (Dr. Michael Howell), and Oregon Health Sciences University/Portland Veterans Affairs (Dr. Miranda Lim).
Aleksandar Videnovic, MD, Massachusetts General Hospital, Harvard Medical School, Boston, MA, talks on the establishment of the North American Prodromal Synucleinopathy (NAPS) Consortium.
As the name suggests, Frontotemporal dementia (FTD) affects the frontal lobe and/or temporal lobes of the brain. Signs and symptoms vary, depending on which part of the brain is atrophying, or shrinking. Genetic mutations and dysfunctional proteins in the brain have been linked to FTD.
In a paper published in The Lancet Neurology, a group of scientists, including NAPS Co-Investigator, Ronald Postuma, MD, MSc (McGill), argue that developing effective treatments for Parkinson’s disease demands a new way of classifying the disease for research purposes, one based not on clinical diagnosis but biology. The authors have called their biological model “SynNeurGe”.
Indu Subramanian (UCLA) speaks with REM Sleep Behavior Disorder (RBD) expert and NAPS Co-Investigator, Ronald Postuma, MD, MSc (McGill), about prodromal Parkinsons's disease and it's link to RBD.
Researchers uncover how brain fats are crucial for memory, identifying genes that could lead to treatments for Alzheimer's. This new understanding of fatty acids opens exciting avenues for neurodegenerative disease therapies.
“By focusing on RBD research, we have an unprecedented opportunity to develop clinical trials aimed at stopping the progression of neurodegenerative disorders, such as Parkinson’s, dementia with Lewy bodies, and multiple system atrophy. I can’t think of more rewarding work.”
– Aleksandar Videnovic, MD, MSc
Massachusetts General Hospital
Many studies have posed a-synuclein as a potential diagnostic and prognostic biomarker for Parkinson's Disease. Due to its abundance in the body, several modes for sample collection are currently being investigated, including tissue and fluid samples.
The professorship was created through a bequest from the late Reuben M. Morriss III and Barbara Burton Morriss to Washington University, to advance Alzheimer’s disease research.
Our team is committed to further the NAPS study's mission to support clinical care, advance discovery, promote education, and engage our community in order to improve the quality of life and care of individuals living with RBD. Learn more about the team at Emory University.
The 2nd Annual Center on Biological Rhythms and Sleep Symposium was held at the Washington University School of Medicine in St. Louis in May 2023.
Our team is committed to further the NAPS study's mission to support clinical care, advance discovery, promote education, and engage our community in order to improve the quality of life and care of individuals living with RBD. Learn more about the team at OHSU and VA Portland Health Care System (VAPORHCS).
Our team is committed to further the NAPS study's mission to support clinical care, advance discovery, promote education, and engage our community in order to improve the quality of life and care of individuals living with RBD. Learn more about the team at UCLA.
Our team is committed to further the NAPS study's mission to support clinical care, advance discovery, promote education, and engage our community in order to improve the quality of life and care of individuals living with RBD. Learn more about the team at The University of Minnesota.
Our team is committed to further the NAPS study's mission to support clinical care, advance discovery, promote education, and engage our community in order to improve the quality of life and care of individuals living with RBD. Learn more about the team at McGill University Health Centre Research Institute.
Our team is committed to further the NAPS study's mission to support clinical care, advance discovery, promote education, and engage our community in order to improve the quality of life and care of individuals living with RBD. Learn more about the team at Washington University.